Coleus Products available :

We can deliver around one metric tonne of coleus soft extract in oleoresin form with Forskolin content 11% to 15% by HPLC per month. We can also supply coleus extract in powder form with 10,20,40% forskolin content by HPLC.

Overview :

This "power" herb has an active ingredient know as forskolin. It has been utilized in ayurvedic medicines for many years. Forskolin's most common mechanism of action is that it increases the amount of cyclic AMP (adenosine monophosphate) in cells by activation of an enzyme called adenylate cyclase. Cyclic AMP (cAMP) is one of the most important secondary messengers in the cell. It is regarded as the most crucial cell regulating compounds.

Under normal circumstances, cAMP builds by adenylate cyclase activation due to hormonal stimulation at the cell receptor site. However, forskolin seems to bypass this reaction and allows for an increase in intracellular cAMP to occur. Why is it important to increase cAMP levels? Well, this benefits athletes. It induces relaxation of the arteries lowering blood pressure, raised insulin secretion (which can help drive carbohydrates and protein into muscle cells for energy and recovery), increased thyroid hormone function (which can help raise metabolic rate), and significantly increase lipolysis (fat burning). Forskolin also benefits different cellular enzymes. The breaking up of fat for fuel (lipolysis) is actually regulated by cAMP. Forskolin enhances lipolysis and also inhibits fat storage.

This is very beneficial for individuals attempting to reduce bodyfat and get lean.  Forskolin also allows fat loss to occur by stimulating thyroid hormone production, which controls metabolic process and can increase metabolic rate, which can result in additional fat loss.

Forskolin also stimulates digestive enzymes, which aid digestion. They are shown to increase nutrient absorption in the small intestine.

Forskolin has been shown to be safe and effective and can be used as a sports supplement.

Coleus forskohlii Supplement Applications

Physiological, biochemical and clinical effects of forskolin include the following:

• Platelets: inhibition of aggregation.
• Red blood cells: prevention of membrane lipids peroxidation in hyperglycemia.
• Adipocytes: increased lipolysis.
• Pancreas: potentiation of insulin secretion.
• Thyroid: increase/potentiation THS, T3, T4.
• HPA axis: increase in CRH, ACTH, steroid genesis.
• Leydig cells: testosterone production.
• Respiratory tract: broncholytic, and anti-asthmatic.
• Genitourinary tract: treatment of vasculogenic impotency in men.
• Eye: decrease in intraocular pressure.
• Skin: management of cellulite, and psoriasis.
• Cardiovascular system: positive inotropic, chronotropic, and hypotensive effects, and improved coronary blood flow and myocardial functions.